Despite taking an early lead through Roman Neustadter, the German side was ultimately undone by strikes from Hamit Altintop and Burak Yilmaz just before the break.

Although Michel Bastos levelled just after the hour, Schalke still needed another as the Turks had scored more away goals and their all-out attack left them vulnerable at the back, with Gala making sure of its progress thanks to Umut Bulut’s injury-time effort.

The Super Lig leader was looking to bounce back from an embarrassing home defeat to Genclerbirligi in its last domestic outing and it started in confident fashion.

Former Chelsea striker Didier Drogba looked imperious early on and Schalke goalkeeper Timo Hildebrand had to be at his best to tip the striker’s fierce effort round the post.

The Ivorian then played in Selcuk Inan, who ran through on goal but lost his balance and his shot did not unduly trouble Hildebrand.

It seemed only a matter of time until the Schalke goal was breached but it was the hosts who took a 17-minute lead very much against the run of play.

The visitors failed to clear their lines from a corner and Joel Matip played the ball back to Neustadter, who slotted home with his outstretched left foot.

The strike seemed to settle Schalke, who had won all three league games since the draw with Tuesday night’s opponent in the first leg.

Wesley Sneijder served notice to the Gelsenkirchen side, however, when he fired narrowly wide from just inside the area before Altintop brought the tie back to life in the 37th minute.

Drogba squared a free kick to the Turkey international 25 yards from goal and his fierce blast went in off the post.

And five minutes later, Gala had taken the lead when Burak shrugged off the challenge of Benedikt Howedes and lifted over Hildebrand for his eighth Champions League goal in as many games.

Jens Keller’s men started the second half in positive fashion and Teemu Pukki — starting in place of injured star striker Klaas Jan Huntelaar — turned on the edge of the box before his rattling low effort was pushed away by Fernando Muslera at his near post.

The Gala goalkeeper was at fault, however, when Michel Bastos levelled in the 63rd minute.

Marco Hoger fired against the crossbar and although it looked like there would be no follow-up, Muslera fumbled and left Atsuto Uchida to square for the Brazilian to fire into an empty net.

Sneijder went close to immediately regaining the lead for Gala but he hammered wide but it was Schalke who gained the upper hand thereafter, with Muslera slightly redeeming himself by smartly parrying away Julian Draxler’s effort.

Gala then had to make a change as defender Semih Kaya was carried off the pitch having been knocked out although that did not seem to affect the Istanbul side, who held firm in spite of some probing pressure from Schalke.

However, the hosts left themselves wide open to the counter in search of a winner and it was Gala who stole up the other end to make sure of their progress to the quarterfinal.

Substitute Umut beat the offside trap in the fifth minute of injury time and beat Hildebrand at the second attempt to send the visitors wild with joy.

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Messi scored in the fifth and 40th minutes, moving into sole possession of second on the Champions League career scoring list with 58 goals. David Villa put Barcelona ahead in the aggregate series in the 55th minute, and left back Jordi Alba sealed the win when he scored in the second minute of stoppage time.

AC Milan, a seven-time winner of Europe’s top club tournament, won the first leg in Italy on Feb. 20 and nearly got a valuable away goal in the 38th minute, but 18-year-old forward M’baye Niang hit a post with an open shot on a counterattack. If he had tied the game 1-1, Barcelona would have needed at least three more goals at that point to advance because away goals are a tiebreaker.

Messi, the four-time FIFA Player of the Year, passed Ruud van Nistelrooy (56) on the Champions League scoring list and trails only Raul Gonzalez (71). With his 18th multigoal game of the season, Messi increased his season goals total to 53.

In the other match, Galatasaray won 3-2 at Schalke to advance on 4-3 aggregate and reach the quarterfinals for the first time since 2001.

Real Madrid, Juventus, Borussia Dortmund and Paris Saint-Germain also are in Friday’s draw. In the final second-round matches Wednesday, Arsenal tries to overturn a 3-1 deficit at Bayern Munich and Porto goes to Malaga with a 1-0 lead.

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Goals by Kroos in the seventh minute and Mueller in the 21st built a 2-0 lead. After Lukas Podolski scored for Arsenal in the 55th, Mario Mandzukic got Bayern’s final goal in the 77th.

The second leg of the total-goals series is in Germany on March 13.

“Let’s not hide the truth,” Arsenal manager Arsene Wenger said, “it will be very difficult. We will try to make the impossible possible.”

In Tuesday’s other game, Joao Moutinho scored in the 56th minute to give Porto a 1-0 win over visiting Malaga.

The first leg ends Wednesday when AC Milan hosts Barcelona and Schalke is at Galatasaray.

While Bayern leads the Bundesliga by 15 points and reached the Champions League final in two of the last three years — losing both — Arsenal is in the midst of the most trying season since Wenger was hired in October 1996.

Arsenal is fifth in the Premier League, 21 points behind first-place Manchester United and four back of rival Tottenham for England’s last berth in next season’s Champions League.

The Gunners, who haven’t won a trophy since the 2005 FA Cup, were knocked out by fourth-tier Bradford in December’s League Cup quarterfinals and were eliminated from the FA Cup’s fifth round by second-tier Blackburn last season.

Now this year’s Champions League title is a longshot.

“You have to give credit for their class,” Wenger said of Bayern. “In patches in the first half, there was a difference in quality.”

Arsenal central defenders Per Mertesacker and Laurent Koscielny had a poor night, with the first goal coming after Bayern collected an errant clearance from Koscielny. Mueller crossed for Kroos, who beat goalkeeper Wojciech Szczesny with an 18-yard volley.

Mueller scored when he poked the ball into an unguarded net after Szczesny parried a header from an unmarked Daniel Van Buyten.

Arsenal’s players were jeered when they walked off at halftime, while Bayern fans sang another rendition of “Football’s Coming Home” in English.

“We didn’t start great and that’s been a thing for us this season,” Arsenal midfielder Jack Wilshere said. “Maybe it’s a bit of nerves or anxiety because we show what we can do when we play.”

Podolski cut the gap when he headed Jack Wilshere’s corner kick into an open net. But Mandzukic finished a sweeping move by bundling in Philipp Lahm’s low cross at the far post, the ball looping up off the Croatian’s heel and beyond Szczesny.

“We are currently in astonishing form,” said Bayern coach Jupp Heynckes, who will be replaced by Pep Guardiola this summer. “Our quality is we can punish even the smallest mistakes of our opponents.”

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